| Tom Cruise | Ray Ferrier |
| Justin Chatwin | Robbie Ferrier |
| Dakota Fanning | Rachel Ferrier |
| Tim Robbins | Ogilvy |
| Miranda Otto | Mary Ann Ferrier |
| David Alan Basche | Tim |
| James DuMont | |
| Yul Vazquez | Julio |
| Daniel Franzese | |
| Michalina Almindo | Refugee |
| Gerald Blakey | Refugee |
| Shanna Collins | Teenager #1 |
| Stellarina Croxon | Survivor - Mother with boy |
| Ambi Daniel | Refugee |
| Crystal Dawne | Starving girl in diner |
| Joseph DeBona | Newark Deliveryman |
| Miguel Antonio Ferrer | Brazilian Neighbor |
| Takayo Fischer | Older Woman #3 |
| Stephen Gevedon | Neighbor |
| Rick Gonzalez | |
| Tommy Guiffre | National Guardsman |
| David Harbour | |
| Grant Hayes | Survivor |
| Amy Hohn | |
| Elizabeth Jayne Hong | |
| John Thompson Hopkins | Survivor |
| Priscilla Hopkins | Survivor |
| Tracy Howe | Mob Onlooker #1 |
| Daniel A. Jacobs | Young Man |
| Freddie Johnson | Boston Survivor |
| Lauri Johnson | Older Woman |
| Johnny Kastl | Soldier |
| George Katt | |
| Vladislav Kozlov | Survivor |
| January LaVoy | Brazilian Neighbor's Wife |
| Christy Lee | Refugee |
| Riley G. Matthews Jr. | Newark Cop |
| Mariann Mayberry | |
| Kirsten Nelson | Business Woman |
| Jorge Pallo | Army Private |
| Dempsey Pappion | Man #3 |
| Rick Pisarro | Swarthy Longshoremen |
| Sharrieff Pugh | |
| Benny Rafael | Staff Sgt. Morales |
| Ann Robinson | |
| Rachelle Roderick | Rhoda, Alien Escapee |
| Cory Rodriguez | Army Soldier |
| Camillia Sanes | News Producer |
| Rafael Sardina | |
| Stacy Sarver | |
| John Scurti | |
| Columbus Short | Soldier #4 |
| Ty Keegan Simpkins | 3 year old boy |
| Channing Tatum | Boy in church scene |
| Patrick Tierney | Extra |
| Ed Vassallo | Intersection Guy |
| Lenny Venito | Manny |
| Travis Aaron Wade | Capt. Bixby |
| Michael Waldron | Newark Cop |
| Lisa Ann Walter | |
| Christopher Evan Welch | |
| Julie White | |
| Christopher Anderson | Boy 2 in Church Scene (uncredited) |
| Claudia Barroso | Portuguese Woman (uncredited) |
| Kevin Kenny | Wounded Ferry Victim (uncredited) |
| Rose Pasquale | Boston Survivor (uncredited) |
